The aim of this bioinformatics research project is to facilitate genomics medicine and include the PGx information layer in the clinical decision process. To this end, the PhD student will start by benchmarking methods for extracting PGx information from whole-genome sequencing (WGS) data. Next, the project will continue with the development of a toolkit for implementing PGx workflows. Finally, the utility of WGS PGx profiles in clinical practice will be assessed and applied on clinal-grade whole-genome sequencing data generated at the Jessa Hospital.
Applicants should hold an MSc degree in bioinformatics, computational Biology, biological disciplines (e.g. biomedical sciences, medicine, bioengineering science or equivalent) or computer science. Master students that obtain such a degree later this academic year can also apply.
Candidates with a biomedical background are expected to demonstrate programming experience (e.g. R, Linux bash, Python).
Candidates with a computational background should demonstrate basic knowledge in genetics.
Developing genomic and cross-omics workflows for processing clinical cohort data and auxiliary data resources.
A strong interest and motivation in genomics and pharmacogenomics applications is desired.
We look forward to receiving a motivation letter (max. 1 page), short CV (max. 3 pages), a transcript from the MSc degree, and three names of referees.
• Applications will be processed on a first come first served basis until a suitable candidate is found.