Position Details
School of Biosciences
Location: University of Birmingham, Edgbaston, Birmingham UK
Full time starting salary is normally in the range £33,348 to £43,155, with potential progression once in post to £45,737
Grade 7
Full Time / Fixed Term contract up to July 2025
Closing date: 22nd June, 2023
Role Summary
The role will primarily include the development, implementation and application of data processing workflows, including experimental design, pre-processing, and statistical analysis of large scale LC-MS based metabolomics studies; collaboration with researchers within and external to the university (academic, industry, scientific instrument manufacturers); and providing training and support in bioinformatics.
Background
The post has been created by a collaboration between the Phenome Centre Birmingham and the new EU H2020 PrecisionTox consortium (www.birmingham.ac.uk/research/centre-for-precision-toxicology/index.aspx ). The post holder will be primarily involved in the application of computational metabolomics to process, annotate and analyse the world's largest comparative, multi-omics toxicological dataset generated as part of PrecisionTox.
The PrecisionTox project, led by the University of Birmingham and involving 15 European and US organisations, blends technology and modern scientific approaches with law to establish a new cost-effective testing paradigm for chemical safety assessment — Precision Toxicology — that revolutionizes regulatory toxicology, replaces animal testing, reduces uncertainty, and determines safety factors in assessing risks to human health.
Main Duties
Develop and implement computational workflows, to be applied in human health and toxicology research, enhancing the capabilities and capacity of the PCB
Perform extensive pre-processing of metabolomics data acquired on the mass spectrometry platforms in the PCB, in particular for the PrecisionTox project
Conduct an array of univariate and multivariate statistical analysis of data acquired on the mass spectrometry platforms, in particular for the PrecisionTox project
Manage and ensure optimal operation of software and other bioinformatics resources so to meet research goals in a timely manner
Curate datasets both locally at Birmingham and at international data repositories
Disseminate high quality research in project reports, articles in peer-reviewed journals, papers at scientific conferences and to the general public
Work with the PCB Directors to achieve the research objectives of the PCB
Carry out administrative tasks related directly to the delivery of the research.
Provide bioinformatics and computational biology training to University staff, students and others
To be a conduit for the multidirectional flow of knowledge and information between the two centres: Phenome Centre Birmingham and PrecisionTox.
Promote equality and values diversity acting as a role model and fostering an inclusive working culture.
Person Specification
First degree in bioinformatics, (bio)chemistry, mathematics, statistics or computer science, and a PhD or equivalent experience in computational metabolomics, chemoinformatics, bioinformatics, biostatistics or a closely related area
High level of experience in the computational analysis of metabolomics data.
High level analytical capability.
Good understanding of principles involved in data processing, including relevant software (e.g. XCMS, Compound Discoverer, etc)
Hands-on skills in bioinformatics, data science or data analytics.
Significant experience in computer programming (e.g. R-language and python).
Experience with unit testing, code refactoring, version control (GIT), and release techniques.
Excellent ability to communicate complex information clearly.
Excellent ability to work within a scientifically diverse team.
Well organised and experience in managing multiple projects simultaneously.
A high level of accuracy and attention to detail.
Ability to work on own initiative, manage time effectively, progress tasks concurrently and work to deadlines, including the ability to work remotely.
Ability to assess resource requirements and use resources effectively, including extensive use of remote resources.
Apply directly via our website: edzz.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_6001/job/2045/