Job Description General Summary :
Research Computing at Boston Children’s supports basic, translational, and clinical research by providing researchers with access to digital tools and technologies. Our computing environment consists of high-performance computing clusters, virtual machines, PetaByte-scale high-performance storage and cloud platforms. We work with BCH scientists to develop solutions in support of cutting-edge research ranging from lattice light-sheet microscopy to CryoEM, genomics, and informatics. The Research Computing Analyst III will be responsible for providing computational support services to Boston Children's Hospital scientists and clinicians by applying a wide range of informatics tools, methods and technologies; with minimal supervision and direction, completing assignments in the required timeframe; consistently adhering to and promoting standard operating procedures and best practices; maintaining and upgrading Research Computing tools, methods and technologies, migrating data, documenting changes, and adjusting internal processes resolving problems associated with assignments and seeking supervisor assistance when needed.
Knowledge, Skills and Abilities :
Extensive knowledge of 1-2 specific technologies used by a specific team and demonstrated knowledge of all other technologies used within the unit. Familiarity with other technologies used by BCH Research Computing. Experience working with biomedical and/or patient-level data, and ability to follow stringent data privacy requirements. Extensive knowledge of technologies used in support of biomedical research, such as programming languages (R, Python, C, Java), scripting (bash, tcsh), databases (SQL), and biomedical software. Experience with using and customizing service request management software, knowledge management, and project tracking systems. Ability to independently resolve a wide range of Research Computing assignments in support of biomedical research; ability to routinely lead projects and coordinate project teams; readiness to seek advice and guidance when needed and to operate effectively in collaboration with scientists and clinicians; ability to follow, improve and create technical documentation and standard operating procedures. Effectively conveying messages through written communication that are tailored to target audience and one-on-one verbal communications are clear and effective; ability to conduct effective meetings, present in departmental and hospital forums, and develop training instructions and manuals; experience with teaching and effective mentoring; ability to effectively engage with scientists and clinicians. Passion for new technologies and science Preference for candidates with understanding of biomedical research environments; experienced with clinical research data types (e.g., whole-exome and whole-genome sequencing, patient-level data, structural biology data), and specific needs of biomedical researchers.
Additional Job Details for Posting Description :
Job Posting Description :
As a Bioinformatics Scientist you will work with researchers who have single-cell RNA-seq, single-cell ATAC-seq, spatial transcriptomics, bulk RNA-seq and ChIP-seq data to investigate the vascular complications of diabetics and other mouse and human diseases as well as with other pediatric scientists at BCH. The primary responsibilities will be building pipelines for the analysis, integration and sharing of these data. You will analyze, integrate different types of next-generation sequencing data and interpret the results and will have the opportunity to publish high-profile papers with prominent authorship depending on the intellectual contribution. The ideal candidate should have enthusiasm for developing collaborative relationships and a desire to foster the use of bioinformatics data in research studies.
You will be responsible for:
Providing computational support services to Boston Children's Hospital scientists and clinicians by applying a wide range of bioinformatics tools, methods and technologies; with minimal supervision and direction, completing assignments in the required timeframe; consistently adhering to and promoting standard operating procedures and best practices; maintaining and upgrading research computing tools, methods and technologies, migrating data, documenting changes, and adjusting internal processed; resolving problems associated with assignments and seeking supervisor assistance when needed.
Routinely leading, co-leading or participating in research computing projects with other members from the BCH research community; setting goals and objectives for projects and demonstrating achievement of those goals and objectives; coordinating work activities with other stakeholders; contributing to the resulting presentations and/or publications.
Effectively tailoring presentations; developing, implementing and maintaining knowledge management systems.
Creating or contributing to a range of compelling communications that clearly deliver content; preparing communications appropriate for management and internal distributions.
Presenting at project and departmental meetings; effectively conveying progress and asserting point of view; constructively discussing issues and providing facts; building credibility and trust by asking thoughtful questions and actively listening; running productive project meetings that advance problem solving.
In order to qualify you must have:
Minimum of 4-year Bachelor's degree in science, technology, engineering or mathematics. Preference for candidates with a Ph.D. in Bioinformatics, Computational Biology or related.
Knowledge of the use of bioinformatics computations in high-performance computing environments, including open-source bioinformatics software and pipelines to support diverse bioinformatics analyses such as single-cell RNA-seq, bulk RNA-seq, ChIP-seq, etc.
Experience working with at least one of the single-cell technologies such as scRNA-seq, scATAC-seq, spatial transcriptomics.
Knowledge of technologies, such as programming languages (R and Python), databases (SQL), version control (Git), scientific workflow tools and high-performance computing clusters.
Ability to routinely lead projects and coordinate project teams; readiness to seek advice and guidance when needed and to operate effectively in collaboration with scientists and clinicians; ability to follow, improve and create technical documentation and standard operating procedures.
Strong publication record. Ability to effectively convey messages through written communication that are tailored to target audiences; meeting discussions and one-on-one verbal communications are clear and effective; to present in departmental and hospital forums and to develop training instructions and manuals; ability to effectively engage with scientists and clinicians.
Boston Children’s Hospital offers competitive compensation and unmatched benefits.