Senior Scientist, Computational Genomics

Vertex Pharmaceuticals. Inc.
Data and Computational Sciences
United States MA Boston


We are seeking a senior computational biologist with expertise in driving forward biological discoveries and therapeutic development to join Vertex. This position is part of a rapidly growing Data and Computational Sciences team focused on Cell and Genetic therapies for human diseases with serious unmet need. You will play a critical key role in evaluating,and developing cutting-edge computational methods that assess the safety and efficacy of the next class of transformative gene editing therapeutics. You will also cross-functionally collaborate with project teams to design, analyze, and interpret large-scale genomic datasets. A strong background in computational methods development and an ability to seamlessly collaborate with team members will be required for success in this role.

Key responsibilities:

• Develop novel computational methods that address key questions regarding the efficacy and safety of gene editing therapeutics
• Leverage and extend best practices from the genomics, statistics, and data science fields to create industry-leading analysis software
• Proactively collaborate with project teams to identify key needs and questions that can be addressed using genomics, sequencing, or bioinformatics
• Lead rigorous computational analyses of sequencing data and other biological data
• Distill complex analyses and results into key take-home messages for a broad audience
• Propose and advocate for public advancements in the fast-paced fields of gene editing and genetic therapies that would accelerate therapeutic development and overcome obstacles


• Ph.D. (or equivalent degree) in computational biology, bioinformatics, human genetics, genomics, systems biology, bioengineering, or a related field and 2-5 years of productive, relevant post-doctoral employment experience, or MS (or equivalent degree) in similar fields and 5+ years of productive, relevant employment experience, or BS (or equivalent degree) in similar fields and 8+ years of productive, relevant employment experience
• A proven track record of next-generation sequencing (NGS) methods development pertaining to variant calling, RNA-Seq, amplicon sequencing or related data types
• A strong programming background, with expertise in python, C++ and/or Rust
• Demonstrated ability to collaborate with experimental collaborators to design studies that answer key scientific questions
• An independent, detail-oriented, and self-motivated approach to problem solving
• A team-oriented mindset that welcomes feedback and supports others
• Strong organizational and time-management skills
• Familiarity with high-performance computing systems and bioinformatics workflow languages
• Excellent presentation and communication skills, including the ability to tailor scientific content to audiences with different backgrounds

Start date

As soon as possible

How to Apply


Thomas Willems