Research Fellow/Senior Research Fellow in Bioinformatics and Computational Biology, - Ref:1876220
atsv7.wcn.co.uk/search_engine/jobs.cgi?SID=amNvZGU9MTg3NjIyMCZ2dF90ZW1wbGF0ZT05NjYmb3duZXI9NTA0MTE3OCZvd25lcnR5cGU9ZmFpciZicmFuZF9pZD0wJmpvYl9yZWZfY29kZT0xODc2MjIwJnBvc3RpbmdfY29kZT0yMjQ=
UCL Department / Division Research Department of Structural and Molecular Biology/Division of Biosciences
Location of position London
Grades7-8
Hours Full Time
Salary
(inclusive of London allowance)Grade 7 £36,028 - £43,533 / Grade 8 £44,737 - £52,764 per annum
Duties and Responsibilities
Designing Novel Protocols for Predicting Biological Processes and Protein Functions associated with Class Switching Events and Antibody Specificity.
Once an antibody has bound their target, its subsequent function depends on the constant region, which can be changed between 9 different classes. Class switching was not previously thought to affect the target specificity. However, we have seen that the control of class switching can be affected by old age, or certain infections. In this project we will investigate class switching and its effect on antibody specificity.
This is an interdisciplinary project involving 4 world-leading research groups (Christine Orengo UCL, Claudia Mauri UCL, Franca Fraternali Kings and Deborah Dunn-Walters University of Surrey). The PDRA in the Orengo Group will be involved in developing novel algorithms that exploit machine learning approaches for predicting and analysing protein networks. The Orengo group already have considerable expertise in exploiting protein networks to predict protein pathways implicated in ageing, development and cancer. In addition, in-house tools that exploit evolutionary data to predict protein functions, tools which have been highly ranked in the independent CAFA assessment, will be extended with protein network and other features to predict proteins implicated in class switching. Structural analyses will also be conducted to understand mechanisms. Predictions will be experimentally tested by the groups of Mauri and Dunn-Walters.
This post is funded for 3 years in the first instance and will be based in the lab of Professor Christine Orengo at UCL.
Key Requirements
To apply at Grade 7 and above, you should hold a PhD in a relevant field (computer science, bioinformatics or computational biology) or be about to submit a thesis. Advanced programming skills and experience of Perl or Python, databases and SQL, Linux or other unix-like operating systems are all essential for the role. Previous experience in bioinformatics research is desirable, especially in protein network analysis, protein function prediction and protein structural analysis. A background in immunology or experience of recent research in this area is also desirable.
If the PhD is yet to be awarded, initial appointment will be at research assistant Grade 6B (salary £31,542-£33,257 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis (including corrections).
In addition to the above, to be appointed at Grade 8 as Senior Research Fellow the successful candidate will have an independent research reputation, with evidence of national recognition of achievement within the appropriate subject area. Evidence of completed research, which has been published, as well as a suitable publication record, and evidence of knowledge transfer/exchange activities is also essential.
To apply at Grade 7 and above, you should hold a PhD in a relevant field (computer science, bioinformatics or computational biology) or be about to submit a thesis. Advanced programming skills and experience of Perl or Python, databases and SQL, Linux or other unix-like operating systems are all essential for the role. Previous experience in bioinformatics research is desirable, especially in protein network analysis, protein function prediction and protein structural analysis. A background in immunology or experience of recent research in this area is also desirable.
If the PhD is yet to be awarded, initial appointment will be at research assistant Grade 6B (salary £31,542-£33,257 per annum) with payment at Grade 7 being backdated to the date of final submission of the PhD thesis (including corrections).
In addition to the above, to be appointed at Grade 8 as Senior Research Fellow the successful candidate will have an independent research reputation, with evidence of national recognition of achievement within the appropriate subject area. Evidence of completed research, which has been published, as well as a suitable publication record, and evidence of knowledge transfer/exchange activities is also essential.
See details on the link
atsv7.wcn.co.uk/search_engine/jobs.cgi?SID=amNvZGU9MTg3NjIyMCZ2dF90ZW1wbGF0ZT05NjYmb3duZXI9NTA0MTE3OCZvd25lcnR5cGU9ZmFpciZicmFuZF9pZD0wJmpvYl9yZWZfY29kZT0xODc2MjIwJnBvc3RpbmdfY29kZT0yMjQ=