The group of Dr. David Casero applies Bioinformatics, Computational Biology and high-throughput sequencing data to analyze gene regulatory pathways in stem cell and immunobiology. We are particularly interested in understanding the establishment and maintenance of normal tissue homeostasis, supported by molecular interactions between members of the tissue microenvironment (e.g., epithelial, mesenchymal, and immune cells) and environmental factors (e.g., signals modulated by the microbiome). With the help of our collaborators, our lab aims to harness the power of multi-omics libraries to generate the novel data-driven hypothesis that can pave the way into future mechanistic and translational studies.
For more information about Dr. Casero’s research please visit: www.cedars-sinai.org/research/labs/casero-lab.html
Our goal is to build a dynamic team dedicated to analyze and interpret multi-omics sequencing datasets in both basic and translational studies. You will join a highly collaborative, interdisciplinary, and cutting-edge environment, and we work together with a team of computational, wet-lab, and physician-scientists. Our collaborative network aims to develop a knowledge-based, integrative effort to better understand the aberrant regulatory networks that underlying IBD pathogenesis and future therapeutic approaches. We have a number of ongoing projects – cross-talk between different cell types advancing tissue homeostasis and regeneration, discovery and single-cell characterization of novel non-coding RNAs, and the integration of non-coding RNA expression signatures into genetic association analyses – that provide an outstanding opportunity for highly multidisciplinary research in a relevant biomedical problem within in collaboration with world-renowned IBD scientists.
The Inflammatory Bowel and Immunobiology Research Institute (IBIRI) is a multidisciplinary basic, translational and clinical research program devoted to discovering the causes of Inflammatory Bowel Disease (IBD) with the goal of improved treatment approaches and prevention. The laboratory of Dr. David Casero is looking for highly motivated computational scientists who are passionate about diving into complex biological data.
Educational Requirements:
Doctorate (PhD) in area directly related to field of research specialization (systems biology, computational biology, bioinformatics, applied mathematics, theoretical physics, computer science)
Experience we are seeking:
Independently works on research projects designed by a mentor (typically the PI) within an area of specialization. Acquires thorough technical and theoretical knowledge of research projects and objectives during one to five (1-5) year post-doctoral appointment
Demonstrated aptitude to perform experimental protocols and procedures, including detailed data collection, and analysis and operation and maintenance of specialized equipment.
Knowledge of safety standards and maintenance of specialized equipment.
Experience in genomics and high throughput data analysis
Significant experience in Python, R, matlab or other major programming languages
Strong mathematical background and analytical skills