Postdoc/Scientist: Long Read Sequencing and Epigenomics

Icahn School of Medicine at Mount Sinai
United States NEW YORK New York


Positions for Postdoc Fellow / Senior Scientist are available at the Mount Sinai School of Medicine (Top-20 medical school in the US) in New York City. Our lab is in the Department of Genetics and Genomic Sciences and the Institute for Genomics and Multi-scale Biology.

Our lab (computation + experiment) pioneered the fast growing field of 6mA epigenomics (6mA was thought to exist only in bacteria, but was recently found prevalent in eukaryotes) beyond 5mC (the one extensively studied in human). Recent work by us and others discovered that not only does 6mA exists in eukaryotes including human, but it also has significant functional roles. A major focus of our lab is to explore this young and promising field of 6mA epigenomes, discover other novel types of DNA modifications, their relationship to well-studied DNA/histone modifications, and make fundamentally new discoveries about human diseases. We have unique expertise in the use of third generation sequencing (single molecule real-time, ~20kbp read length, and the emerging nanopore technique) with advantages of detecting different types of DNA modifications, single molecule-level epigenetic phasing, full-length transcript isoforms, complex structural variations.

Recent publications: Nature Biotechnology, 2018 * Genome Research, 2018 * Nature, 2016 * Cell Reports, 2016 * Nature Communications, 2015 * PLoS Genetics, 2015 * Biological Psychiatry, 2015 * Nature Communications, 2014 * Molecular Psychiatry, 2014 * PLoS Genetics, 2013 * PLoS Computational Biology, 2013 * Nature Biotechnology, 2012 * Genome Research, 2012

Lab page with details:


Successful candidates will have unique opportunities to i) build on our unique expertise in 6mA epigenomics and third-generation long read sequencing, large scale collection of clinically relevant samples and a strong network of collaborators, ii) take the lead role in projects developing cutting edge technologies and innovative applications with high biological, biomedical and clinical impact. Compensations for successful candidates are highly competitive. Subsidized housing (in New York City) is also available.

General requirements: 1) Solid training in bioinformatics and statistics with next-gen data (DNAseq, RNAseq, ChIPseq etc.) experimental skills is a plus but not required. 2) Ability to learn and master new technologies and skills, 3) Abilities to lead an independent research direction while adapting to a collaborative environment, 4) An innovative yet critical thinker.

Start date

To be determined

How to Apply

How to apply: Please send the following to 1) A brief cover letter, 2) CV with a list of publications, 3) PDF files for the papers in which you are first or co-first author.

Thank you for the interests!

Gang Fang, Associate Professor, Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, US


Gang Fang