Postdoctoral Researcher in RNA bioinformatics
Tollervey lab
Wellcome Centre for Cell Biology (WCB)
Edinburgh, Scotland
The Tollervey lab aims to understand the nuclear pathways that synthesize and process newly transcribed RNAs, the assembly of RNA-protein complexes and the surveillance activities that monitor their fidelity. To achieve these goals, we have developed and are applying a range of high-throughput techniques for mapping RNA-protein and RNA-RNA interactions.
We are seeking a postdoctoral researcher to help develop and apply bioinformatics approaches to problems at the interface between epigenetics and RNAs biology. Key project include: 1) Analyses of links between chromatin modification, promoter and other sequences and the fate of the RNA transcript. In particular, we want to understand the basis of the distinct fates of protein coding mRNAs, which are generally relatively stable and exported to the cytoplasm, relative to the plethora of non-coding RNAs, most of which are unstable and nuclear retained. 2) Links between RNA processing on the nascent transcript and the elongating RNA polymerase. Our recent results implicate highly conserved ubiquination events in the information flow from the processing machinery back to the transcribing polymerase. Work on these projects will be assisted by interactions with the Bioinformatics Core in WCB, which is led by Dr. Alastair Kerr.
Applicants should hold a PhD or equivalent degree, with a proven track record in research. Expertise in the analysis of high-throughput sequence data and/or genomic data would be highly desirable.
Starting date flexible.
For further information please contact:
David Tollervey
Wellcome Centre for Cell Biology
University of Edinburgh
e-mail: d.tollervey@ed.ac.uk
Ph.D.
e-mail enquiry to : d.tollervey@ed.ac.uk