Exploiting evolutionary data and protein networks to predict protein functions and the impact of genetic variations on these functions.
Applications are invited for a 3 year Postdoctoral Research Associate to work in the Group of Professor Christine Orengo at UCL. The project is in collaboration with experimental groups at UCL.
CATH is a comprehensive protein domain family resource combining sequence, structure and functional data for over 90 million protein domains. This project will improve the classification of domains into functional families and the exploitation of this family data and protein network data in the prediction of protein molecular functions and biological processes. Various machine learning strategies will be explored. In addition, web-based platforms will be developed reporting the impacts of genetic variations on these functions. Predictions will be tested experimentally through collaboration with Professor Jurg Bahler, UCL.
The PDRA will be involved in the following activities:
- Developing improved workflows for classification of protein functional families and their use in protein function prediction.
- Developing analysis programs for assessing the impacts of genetic variations on a protein’s function.
- Development and maintenance of a public website and an in-house database reporting protein functions and the impacts of genetic variations on these functions.
- The candidate will be part of the CATH-Gene3D team and contribute to the development of this well-established international resource.
Grade: 7-8
Hours: Full time
Salary (inclusive of London allowance): £34,635 - £50,753 per annum
This appointment is subject to UCL Terms and Conditions of Service for Research and Support Staff.
If you have any queries regarding the vacancy or the application process, please contact Jeremy Guyer, jeremy.guyer@ucl.ac.uk. The closing date for applications is 30th July 2018 at 5pm (UK local time).
The ideal candidate must have an MSc or PhD in a relevant field (computer science, bioinformatics or computational biology). Experience of web programming, Perl/Python, Linux and SQL are desirable. Previous experience in bioinformatics research, especially in structure-function analysis of proteins, protein networks and machine learning is desirable.
Please contact Jeremy Guyer (jeremy.guyer@ucl.ac.uk) regarding the application process.