The Computational Biologist, working with limited supervision and reporting to the Director of the Single Cell Biology Laboratory, will participate in the collaborative single cell biology program aligned with institutional strategy and direction and make leading contributions to the cutting-edge projects at The Jackson Laboratory. They will be tightly integrated with the wet lab biologists within the Single Cell Biology Laboratory and have direct access to, and guidance from, the JAX Computational Sciences team. The successful candidate will be intimately involved in all single cell projects initiated by JAX faculty and other divisions across the JAX organization in addition to collaborating with clinical and industry partners. Projects will span a diverse array of biomedical disciplines such as cancer biology, ageing, immunology, infectious diseases, metabolism, neural disorders, muscular disorders, stem cell and developmental biology but have a particular emphasis on developing precision medicine applications applied to cancer. Over the past 2 years the Single Cell Biology Laboratory has generated over 2 million single cell transcirptomes and is actively engaged in imaging mass cytometry in addition to numerous other data types to visualize biology at single cell resolution.
While the successful candidate will have primary responsibility for providing a robust and innovative computational pipeline for single cell biology workflows, the ideal candidate will have a very strong computational skill set and, while not essential, have some wet lab cell/molecular biology experience. It is expected the candidate will train current single cell laboratory wet lab scientists in computational methods and in turn be involved in the design of wet lab single cell biology protocol development and experimentation. The candidate will additionally be expected to drive and/or contribute to publications and grant applications.
The position is located in Connecticut. They are expected to sustain collaborations with The JAX research staff and faculty on both the Farmington, CT and Bar Harbor, ME campuses and to visit Bar Harbor on an occasional basis.
Key Responsibilities:
Design, develop and operate computational pipelines for analysis of high throughput single cell data.
Provide computational support for all single cell biology projects.
Participate in data processing, programming and algorithm development.
Participate in evaluation of new technology platforms, assays and software.
Requirements:
Ph.D. or MS in a relevant discipline with 2+ years’ experience in Bioinformatics or Computational Biology. Exceptional candidates may be considered without experience.
Some knowledge of mammalian biology, preferable through wet bench experience.
Aptitude to work in a team environment.
Programming experience in Python and R, with additional experience in Java, C/C++, and Perl and asset.
Proficiency in UNIX scripting and various bioinformatics tools and databases.
Experience in analysis of large multi-dimensional genomic datasets.
Experience in developing computational pipelines and algorithms for genomic/transcriptomic research and/or multidimensional cytometry data.
Deep knowledge on sequencing technologies.
Apply online at www.jax.org/careers or email CV to careers@jax.org and include Job ID number in subject line.