The Hinson laboratory at The Jackson Laboratory for Genomic Medicine in Farmington, CT is seeking a talented individual experienced in computational biology, cell and molecular biology.
The focus of the Hinson laboratory is to understand the molecular and genetic basis of inherited cardiac disorders. We employ diverse approaches but we are particularly focused on the development of novel, biomimetic tissue models of cardiomyopathy using disease-specific induced pluripotent stem cells (iPScs). The Hinson lab also performs genome engineering of stem cells with CRISPR/CAS9 and TALE nucleases, in vitro cardiac differentiation, flow cytometry, NGS assays especially RNAseq and single cell RNAseq, and basic microfabrication. We are seeking a highly-motivated individual who has prior experience with computational methods focused on NGS data analysis, and some previous exposure to molecular biology and cell culture techniques.
The successful candidate will be hired as either a Research Intern or a Research Assistant III, dependent on experience. The Research Intern is a temporary position lasting up to 36 months designed specifically for recent graduates with a 4-year degree looking to advance their scientific/research training prior to pursuing further educational endeavors, whereas the Research Assistant III is a permanent position requiring more developed skills and experience.
Key Responsibilities:
Applies knowledge of the scientific principles, methods and processes (technical and/or theoretical) to conduct a systematic and objective inquiry including experimental design, data collection and analysis; operate instruments and equipment; and use of related information technology.
Performs tests, procedures and experiments applying specialized skills, knowledge and equipment; modifies and refines techniques and procedures to meet research objectives; manages multiple, concurrent projects or a multi-faceted project. Trouble shoots new protocols.
Monitors and maintains sample databases, collects research data to assess accuracy, validity, and integrity.
Coordinates and manages facilities, equipment, supplies and related resources; monitors environmental risks and quality control; understands and complies with safety standards to maintain a safe environment.
Clearly and concisely conveys information verbally and in written form; effectively presents ideas to individuals or groups to ensure that they understand the information and message. Presents research results and summaries; adheres to reporting requirements of research project(s).
Requirements:
Research Intern (Temporary position - 36 months): Knowledge of biological sciences as would normally be acquired through a 4-year degree in biological sciences/engineering, and a desire to advance scientific/research training prior to pursuing further educational endeavors.
Research Assistant III (Permanent position): Knowledge of biological sciences as would normally be acquired through a Bachelor’s or Master’s degree in biological sciences/engineering and 1+ years of directly related laboratory experience. Other means of acquiring that knowledge and experience may be evaluated on a case-by-case basis.
Required skills and experiences include computational methods for NGS sequencing data (e.g. RNA-seq, ATAC-seq and amplicon analyses), R programming and biostasticial analyses.
Desired skills and experiences include stem cell tissue culture especially human iPScs/EScs, in vitro differentiation, DNA and RNA extraction and analysis, immunohistochemistry, flow cytometry, basic microfabrication and photolithography.
The candidate should be hardworking, able to work independently, have strong written and communication skills, able to work in a team environment, acquire new skills rapidly, and have versatility in a laboratory setting.
Strong organizational and communication skills.
Strong analytical and computer skills, proficiency with Microsoft Access, Excel, Word, and Outlook.
Effective problem solving and interpersonal skills.
Willing to work weekends as needed.
Apply online at www.jax.org/careers or email CV to careers@jax.org and include Job ID number in subject line.