The Ke Lab invites one Associate Research Scientist to join at The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (www.jax.org/research-and-faculty/faculty/shengdong-ke). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanism of RNA, the Ke lab utilizes multidisciplinary approaches, including cutting-edge computational biology, biochemistry, innovative bio-technologies, genetics and molecular biology. We are especially interested in m6A RNA biology: 1) the fundamental mechanism of m6A RNA biology, and 2) the biological effects of m6A regulation in nerve system, using mouse and human iPS models. (References: 1] Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2] Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation, Genes & Development 2015, 29:2037-53.)
Qualified candidates would be self-motivated and career oriented individuals, have a genuine interest in addressing complex biological questions and a PhD or MD with background in one or multiple areas, including computational biology, biochemistry, molecular biology, biotechnology, neurosciences, immunology, stem cell, or cancer biology. Skills of quantitative programming or biochemistry are particularly preferred but not required.
Key Responsibilities:
Development, optimization and validation of experimental design.
Synthesis of data into succinct, reproducible and understandable reports/presentations for distribution.
Work with scientific and support staff to assist in grant preparation, with particular reference to experimental design, samples sizes, and statistical/analytical methodology.
Working with other researchers to use and develop end product.
Applying for grants to continue/expand research.
Required Skills
PhD in genetics, biochemistry, molecular biology, cell biology, computational biology or other relevant field
Three (3) years of postdoctoral training or equivalent research experience, and demonstrated meritorious scientific performance.
Strong publication record (two or more peer-reviewed publications).
Ability to integrate and apply feedback in a professional manner, prioritize and drive to results with a high emphasis on quality, and work as part of a team.
Laboratory background with appropriate work experience or with proven ability for practical application of theoretical knowledge.
Proven ability to analyze and synthesize information, and demonstrated resourcefulness in finding appropriate solutions to problems and initiative in presenting alternatives and implementing solutions to ensure effective change and/or eliminate or mitigate potential negative effects.
Exceptional organizational and project management skills, including the ability to plan, schedule, and successfully carry out multiple projects at the same time to successful conclusion with minimal supervision.
Quality orientated including delivering accuracy and attention to detail.
Apply online at www.jax.org/careers or email CV to careers@jax.org and include Job ID number in subject line.