Calico is seeking a computational biologist to join a team of scientists investigating aging and age-related diseases using genetics and functional genomics in humans and a diversity of model systems.
Genomics offers rich, informative profiles of organism state during aging. We collect these data to build causal models for organism state, that reveal the critical underlying cellular processes and more readily highlight promising intervention points. The ideal candidate is passionate about working to better understand how genomes work and their role in propagating the harmful changes that occur during aging.
Predictive modeling with cutting edge machine learning tools are at the core of this work, exemplified by recent publications modeling regulatory activity as a function of DNA sequence using deep learning.
Kelley et al. Sequential regulatory activity prediction across chromosomes with convolutional neural networks. Genome Research, 2018. doi: 10.1101/gr.227819.117.
Kelley et al. Basset: learning the regulatory code of the accessible genome with deep convolutional neural networks. Genome Research, 2016. doi: 10.1101/gr.200535.115.
This work benefits from world-class computing infrastructure and continued collaboration with top machine learning researchers via Alphabet.
- PhD in computer science or biology, or similar demonstration of research ability and experience
- Strong computational fundamentals including machine learning, algorithms, and data structures
- Experience with large datasets and high performance computing
- Strong biological knowledge and interest; familiarity with biological data resources
- Completion of (at least) one research project using functional genomics data
- Experience in human genetics, preferred but not required
- Experience in single cell genomics, preferred but not required
Responsibilities:
- Develop novel machine learning approaches for biological sequence analysis
- Work closely with experimental biologists to analyze large-scale datasets to reach biological conclusions that inform Calico’s pursuit
- Communicate research via publications, presentations, web interfaces, and open software
Please apply on the company website.