The Biosciences and Biotechnology Division of the Physical and Life Sciences Directorate has an opening for a Post-Doctoral Research Staff Member to conduct research in the areas of computational systems biology. This is a two-year Postdoctoral appointment with the possibility of extension to a maximum of three years. Eligible candidates are recent PhDs within five years of the month of the degree award at time of the employment offer.
The research will focus on development of detailed system-level models of metabolism in microbial communities for examination of biochemical mechanisms of intercellular interactions; as well as, assessing phenotypic capabilities of organisms, and analysis of intercellular interactions with the aim of improving production of specific metabolites. This research will involve development of multiple types of models including both genome-scale steady state models, as well as reaction-transport dynamic models. Some of the modeling efforts involve use of LLNL’s high performance computing. The purpose of this appointment is to promote cutting-edge science and requires day-to-day interactions with experimental biologists.
ESSENTIAL DUTIES
- Conduct research in computational microbiology in the areas of microbial ecology and bioenergy research.
- Develop genome-scale models of metabolism in bacteria and algae
- Develop spatially multiscale dynamic reaction and transport models of biophysical systems.
- Investigate the system-level underpinnings of processes involved in symbiotic interactions between algae and bacteria in co-cultured communities.
- Examining interaction between microbes and the surrounding medium using methods such as dynamic flux balance analysis (FBA).
- Contribute to the conception, design and execution of experiments and in silico analyses to address defined problems.
- Communicate with experimental biologists for systems biology studies.
- Develop new computational tools for high performance computing studies.
- Work in a collaborative multidisciplinary team environment to accomplish goals.
- Publish research in peer-reviewed journals and present research at conferences.
ESSENTIAL SKILLS, KNOWLEDGE AND ABILITIES
- Recent PhD in microbiology, bioengineering, computer science, chemistry/biochemistry, physics or related field.
- Demonstrated understanding of the concepts of microbial physiology (particularly metabolism), systems biology and dynamics of multi-cellular communities.
- Previous experience in mathematical modeling of networks.
- Demonstrated effective communication skills through publication of journal articles and presentations at seminars and scientific meetings.
- Demonstrated leadership skills with desire and ability to work in a collaborative, multidisciplinary team environment.
DESIRED SKILLS, KNOWLEDGE AND ABILITIES
- Familiarity with programming for parallel computing.
- Experience using tools of linear programming and operations research.
- Experience in bioinformatics and computational analyses.
- Familiarity with system-level modeling methods like FBA and tools like COBRA.
SPECIAL REQUIREMENTS
- Pre-Placement Medical Exam: None required.
- Pre-Employment Drug Test: External applicants selected for this position will be required to pass a post-offer, pre-employment drug test.
- Anticipated Clearance Level: None.
Apply online at the LLNL's career website at: careers-llnl.ttcportals.com/ The posting number is: 103731
For further consideration or questions contact Dr. Ali Navid (navid1@llnl.gov)