The Institute for Computational Genomics RWTH Aachen University performs research on computational methods for analysis of transcriptomics and genomic data for understanding molecular mechanisms driving cell differentiation and the onset of diseases. Over the past years, we have developed methods for prediction of cell specific binding sites from open chromatin data (Gusmao et al., Nature Methods, 2016), inference of regulatory networks driving cell differentiation (Lin et al., NAR, 2015; Allhoff et al., Bioinformatics, 2015) and prediction of long noncoding RNA regulation via DNA-RNA interaction (Kalwa et al., NAR, 2016).
We invite applicants for a PhDd Candidate position in methods for integrative analysis of transcriptomic and genomic data for characterization of stem cells and cancer progression. Candidates will perform research on methods, for oder “for”? integrative analysis of transcriptome, exome sequencing and methylome from mouse and human Pancreatic tumours and differentiating human pluripotent stem cell culturesand exome sequencing data.
This project is performed in tight collaboration with Prof. Dr. Alexander Kleger from the Ulm University Hospital.
The Kleger lab has key expertisesexpertise in the investigation of pancreatic cancer and pancreatic development u. Using genetically engineered mouse models as well as human pluripotent stem cell models. We There is a wet-lab sethave set up for all state of the art tools to work with mice including orthotopic transplantation of tumours cells but also pancreatic organoids. In addition, we they have built up novel protocols for directed exocrine/ductal differentiation in 3D-organoid culture assays to study a set of pancreatic diseases. Research success is mirrored in a successful track record as given by recent publications in e.g. Nature Communications, Gastroenterology, GUT etc.
Applicants should hold a M.Sc. in Bioinformatics or Computer Science. Experience in the analysis of transcriptomic or genomic data is required. The candidate should have solid programming skills (C, Python and/or R) and acquaintance with Linux. The ideal candidate has dual career track with solid knowledge in biology and cancer medicine. Experience with high performance computing is a plus. The current contract will be limited to two years, with possibility for extension. due to funding restrictions but a three year period is planned. The ideal candidate has dual career track with solid knowledge in biology and cancer medicine. The working language of the group is English.
Interested candidates should send a brief statement of research interests, CV and the names of three refereences to jobs@costalab.org. The Institute for Computational Genomics is part of the Joint Research Center for Computational Biology;, RWTH Aachen University Hospital and the Helmholtz Institute for Biomedical Engineering, RWTH Aachen. The current contract will be limited to two years due to funding restrictions but a three year period is planned.