We are looking for three postdoctoral bioinformatics fellows and a software analyst or engineer to join the multidisciplinary research projects of our teams focusing on the genomic basis of DNA repair defects, genome instability and intra-tumor genetic heterogeneity. We are especially interested in the evolution of these processes in breast, endometrial, and head and neck cancers.
For the postdoctoral positions, we are looking for highly motivated postdoctoral fellows with great communication skills and collaborative spirit. Projects will focus on investigating inter- and intra-tumor genetic heterogeneity in cancers. Specific topics of research include i) understanding disease progression from in situ to invasive breast cancer, from invasive breast cancer to metastatic disease, and resistance to specific therapeutic agents using high-depth bulk tumor, single-cell and plasma DNA sequencing, and ii) understanding the consequences of DNA repair defects on the biology of cancers and as drivers of intra-tumor genetic heterogeneity. Our teams apply a combination of pathology tools and cutting-edge genomics methods to understand the biological basis and clinical impact of intra-tumor genetic heterogeneity, and to discover and validate novel biomarkers to guide the therapy of cancer patients on the basis of specific DNA repair defects. For these positions, applicants should hold a PhD degree in a computational or biological field with extensive experience in bioinformatics, and proven track record in massively parallel sequencing data analysis. The ability to communicate clearly with non-informatics personal would be a bonus.
We are also looking for a bioinformatics software analyst or engineer to maintain, develop and execute our massively parallel sequencing pipeline. We have a cutting-edge pipeline, which is used for numerous whole-genome, whole-exome, targeted capture and RNA sequencing projects, and are keen to keep this pipeline state-of-the-art and to further develop it to address current challenges in cancer genomics. Applicants for this position should hold a BSc, MSc or PhD degree in bioinformatics, computational biology or software engineering. An extensive knowledge of general purpose programming languages such as R, Perl, Python and shell is essential as is previous experience with GATK, samtools and other widely used massively parallel sequencing tools. Experience with dispatching and monitoring jobs on a high performance cluster using LSF and/or PBS as well as pipeline automation through Makefile and/or Snakemake would be highly desirable.
Our laboratories offer a multidisciplinary and vibrant environment, with molecular biologists, pathologists, clinicians, statisticians, and computer scientists working together to address fundamental questions in cancer evolution and DNA repair by utilizing a variety of different techniques. Currently, our team has one bioinformatics analyst and six bioinformatics post-doctoral fellows in addition to lab bench researchers. We are seeking to expand our bioinformatics teams to optimize the way data currently being generated in our in-house projects. We offer competitive salaries and benefit packages. The positions are available immediately.
Informal inquiries may be made to Jorge Reis-Filho at reisfilj@mskcc.org, Britta Weigelt at weigeltb@mskcc.org, Nadeem Riaz at riazN@mskcc.org and Ronglai Shen at shenr@mskcc.org.