Bioinformatician position available at Sloan-Kettering, New York City
We seek a motivated bioinformatician to be involved in our studies of gene regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines computational and experimental approaches to annotate and functionally elucidate small RNA pathways, mRNA processing and modification pathways, and transcription factor networks. Towards this end, we produce small RNA, RNA-seq and ChIP-seq data, and analyze these with respect to the rich comparative genomic data available for Drosophila and mammals. There is a close exchange of ideas between dry and wet lab members to generate and test biologically-based hypotheses.
The position will integrate into several related projects regarding post-transcriptional regulation, including mechanisms of small RNA biogenesis, tissue-specific alternative polyadenylation, and in vivo regulation by m6A/RNA methylation.
Recent Selected References
Dai, Q., A. Ren, J. O. Westholm, H. Duan, D. J. Patel and E. C. Lai (2015). Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Genes and Development 29: 48-62.
Wen, J., H. Duan, F. Bejarano, K. Okamura, L. Fabian, J. A. Brill, D. Bortolamiol-Becet, R. Martin, J. G. Ruby and E. C. Lai (2015). Adaptive regulation of testis gene expression and control of male fertility by the Drosophila hairpin RNA pathway. Molecular Cell 57: 165-78.
Bortolamiol-Becet, D., F. Hu, D. Jee, J. Wen, K. Okamura, C.-J. Lin, S. L. Ameres and E. C. Lai (2015). Selective suppression of the splicing-mediated microRNA pathway by the terminal uridyltransferase Tailor. Molecular Cell 59: 217-228. (Highlighted in Molecular Cell 59: 141-143).
Wen, J., E. Ladewig, S. Shenker, J. Mohammed and E. C. Lai (2015). Analysis of nearly one thousand mammalian mirtrons reveals novel features of Dicer substrates and miRNA evolution. PLoS Computational Biology 11 (9): e1004441.
Kan, L., A. V. Grozhik, J. Vedanayagam, D. P. Patil, N. Pang, K.-S. Lim, Y.-C. Huang, B. Joseph, C.-J. Lin, V. Despic, J. Guo, D. Yan, S. Kondo, W.-M. Deng, P. C. Dedon, S. R. Jaffrey and E. C. Lai (2017). The m6A pathway facilitates sex determination in Drosophila. Nature Communications 8: 15737, 1-16.
Kondo S., J. Vedanayagam, J. Mohammed, S. Eizadshenass, L. Kan, N. Pang, R. Aradhya, A. Siepel, J. Steinhauer and E. C. Lai (2017). New genes often acquire male-specific functions but rarely become essential in Drosophila. Genes and Development 31: 1841–1846. (Highlighted in Genes and Dev 31: 1825-1826.)
Relevant candidates will have strong computational skills and experience with deep-sequencing data, comparative genomics and statistics. Postdoctoral fellows or BA/MS level candidates seeking experience before graduate school will be considered.
Please send letter of inquiry, CV and references to laie@mskcc.org.