Postdoctoral position in computational detection of RNA-DNA triple helices

RWTH Aachen
Germany Aachen


The Institute for Computational Genomics, RWTH Aachen University performs cutting edge research on computational and genomic methods for understanding regulatory and epigenetic processes driving cell differentiation and diseases. In this project, we are particularly interested in studying RNA-DNA interactions as mechanisms of transcriptional control. For example, we have recently shown how the long-noncoding RNA HOTAIR interacts with DNA via triple helices to control the expression of stem cell differentiation (Kalwa et al., NAR, 2016).


We are looking for a postdoc candidate to work on sequence analysis algorithms for detection of RNA-DNA triple helices and for analysis of novel target sequencing protocols, which capture triple helix forming RNA and DNA molecules. This project will be performed in collaboration with cell biologists of the Medical Faculty, RWTH and of the German Centre of Cancer Research (DKFZ), Heidelberg.

Applicants should hold a Ph.D. in Bioinformatics or Computer Science. Experience in the analysis of biological sequences and regulatory genomics is required. The candidate should have solid programming skills (C, Python and/or R) and acquaintance with Unix/Linux. Experience with high performance computing is a plus. The working language of the group is English. The position is a full time position to be filled as soon as possible. The candidate will have the possibility to perform his habilitation. The salary corresponds to level 13 TV-L.

RWTH Aachen is one of the members of the German Excellence Initiative and one of the leading technical universities in Europe. It is located at the Euroregio tri-border region neighboring Netherlands and Belgium, which provides unique life and work opportunities. We particularly welcome and encourage applications from women, disabled people and ethnic minority groups, recognizing they are underrepresented across RWTH Aachen University. The principles of fair and open competition apply and appointments will be made on merit.

Start date

As soon as possible

How to Apply

Interested candidates should send a brief statement, of research interests, CV and the names of three references to


Ivan G. Costa