We are looking for somebody to join the group of Prof Julian Gough to work on a project funded by AstraZeneca to work on Blue Skies research on cell fate control in murine models of immune oncology and lung repair.
We have created a system ‘Mogrify’ based on cellular networks to predict transcription factors for reprogramming one human cell type into another (Rackham et al. Nature Genetics 2016). This has been experimentally validated by proving several novel conversions, and we are validating many more. Working closely with AstraZeneca murine models of immune oncology and lung repair we will investigate the use of small molecules for cell reprogramming in mouse. The work is anticipated to be predominantly computational and theoretical but will also include laboratory work in transcriptomics.
The successful applicant will be awarded a 2 year Career Development Fellowship/MRC Postdoctoral Training Scheme. The fellowship is a training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, or is moving into a new research discipline. There will also be the opportunity to work closely with AstraZeneca.
Candidates will be highly motivated, have a PhD in a relevant subject, and have an aptitude for theoretical work and data analysis. Candidates should have experience of and ability to perform techniques relevant to the project. Particularly useful would be experience of computational research. The post is available to applicants with varying computational experience. Applicants with no formal training in computational or mathematical work but who enjoy it, have self-taught to a high level, the aptitude and are keen to learn will be considered, if they have other complimentary biological qualifications, knowledge and experience. Conversely computer or technical scientists with no formal training in molecular biology will be considered if they have a powerful interest and motivation in molecular biology and are driven to learn.
Via web:
mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/645