Postdoctoral Fellowship - Single-cell systems biology and systems immunology

St. Jude Children's Research Hospital
Computational Biology
United States Tennessee Memphis


The Lab of Jiyang Yu in the Department of Computational Biology is seeking outstanding candidates for a postdoctoral research associate focused on single-cell systems biology and systems immunology. The Yu Lab is interested in developing systems biology algorithms, including NetBID (Du et al., Nature 2018), by integrating multi-omics data at both bulk and single-cell levels, to dissect the intracellular and intercellular network wiring and rewiring in healthy and disease conditions, as well as the underlying hidden drivers, and then translate the discoveries into potential clinical applications. The candidate will develop computational and systems biology approaches for network and hidden driver analysis from single-cell omics data (e.g., scRNA-seq, scATAC-seq, single-cell proteomics, and spatial transcriptomics). The successful applicant will work in a dynamic environment, performing integrative analysis of multidimensional datasets in the context of basic immunology and cancer immunotherapy.


Candidates must hold a doctoral degree (PhD, MD, or equivalent). Applicants with a PhD in a quantitative field (computational biology, bioinformatics, systems biology, genetics/genomics, statistics, mathematics, computer science, or related fields) are encouraged to apply. Strong candidates from a primarily wet-lab or clinical background who wish to develop sophisticated quantitative skills will also be considered. Successful candidates will have a track record of scientific productivity, e.g., a first author paper, or a demonstrable contribution to a large project. Experience in immunology or cancer immunotherapy or single-cell technologies is desired. The initial appointment will be for 1-2 years and can be renewed for up to a total of 5 years, depending on the candidate’s goals and qualifications.

Start date

As soon as possible

How to Apply

If interested, email your CV and contact information for three reference providers to Please reference this advertisement in your message.


Deanna Tremblay