A postdoctoral position is available in the lab of Daniel Savic in the field of pharmacogenomics. The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of pediatric leukemia in order to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and leukemia relapse. To address these critical questions, the Savic laboratory applies functional genomic and high-throughput approaches to identify and functionally characterize cis-regulatory elements and their associated noncoding sequence variants. The long-term goal is to gain a better understanding of the genetic underpinnings of chemotherapeutic drug resistance and relapse in pediatric leukemia.
The candidate should have prior training in gene regulation and experience performing and/or optimizing functional genomic assays (e.g. ChIP-seq, ATAC-seq, Hi-C, etc.), as well as an excellent understanding of next-generation sequencing technology. Experience with a programming language and a strong background in statistical genetics is highly desirable.
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