A postdoctoral research fellow position is available to study the role of enhancer elements in drug resistance of breast and ovarian cancer in the laboratory of Functional Epigenomics led by Dr. Alexandre Gaspar Maia at Mayo Clinic. The position is better suited for a bioinformatics expert with strong interest in epigenomic and single cell analysis. In the lab we have unprecedented access to patient derived xenograph models, tumor organoid cultures and circulating tumor cells from breast and ovarian cancer patients, that will help us identify enhancers specific to the oncogenic potential. We are interested in identifying novel biomarkers of drug resistance by exploiting a broad range of some of the most advanced techniques in epigenomic profiling (ATAC-seq) and genome editing-based screens (CRISPR). One specific interest is PARP inhibitor and chemotherapy resistance in ovarian and breast cancer. The research team collaborates with other scientists and clinicians at Mayo Clinic to access samples and clinical data that can inform the functional studies and create the most accurate hypotheses for translational research.
Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Knowledge and experience with sequencing technologies, R and/or python is required. Previous experience with single cell analysis is preferred but not required.
For your application include a single PDF with a one-page research statement (detailing your research interests and your short- and long-term career goals), your CV, and the contact information for 2-3 references. Apply until December 31st, 2019 in order to guarantee consideration.